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Category: Practice booksBetatrophin correlates with adiponectin and is not affected by oral glucose tolerance in children and young adults.
Betatrophin is a novel hormone, which is increasing in obesity. In contrast to the well-established anti-obesity peptide adiponectin, little is known about the role of betatrophin in childhood obesity. In this study we investigated the potential association of betatrophin with obesity indices, glucose tolerance, insulin sensitivity, and other potential modulating factors. Therefore, we investigated betatrophin as a novel obesity and glucose tolerance marker. We enrolled 130 children and young adults with normal (NGT; n = 74) and impaired (IGT; n = 56) glucose tolerance at a cross-sectional setting. We additionally included body composition, biochemical and insulin parameters, 25-hydroxyvitamin-D and vitamin-K measurements. We detected significant correlations of betatrophin with several anthropometric and metabolic variables. Overall, we identified no impact of betatrophin and adiponectin on the relationship between glucose tolerance and body mass index (BMI). Moreover, we found no correlation between betatrophin and total adiponectin protein levels. In contrast, the ratio of betatrophin to total adiponectin significantly correlated with glucose tolerance, independent of BMI, adiponectin levels and fat distribution. Our findings demonstrate for the first time that betatrophin is strongly associated with glucose tolerance in children and young adults. However, it is not affected by adiponectin. Therefore, the ratio of betatrophin to adiponectin might be an attractive novel marker for metabolic disorders.Epilepsy and children’s play.
Of the psychiatric consequences of childhood epilepsy, play seems to be the least studied. While developmental disability is commonly considered to be most strongly associated with childhood epilepsy, the evidence for this and other conclusions about the relationship between epilepsy and developmental disability is reviewed. Evidence that epilepsy per se has an adverse effect on play is discussed and suggestions are made about how it might be investigated. Recent data from a large sample of children with epilepsy
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