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The cyclin-dependent kinase Greatwall regulates cell cycle progression in vertebrates and fission yeast. We previously showed that the fission yeast ortholog Great1p can function as a negative regulator of mitotic entry and progression in a temperature-sensitive background. Here we show that SIZ1, the fission yeast Great1p homolog, has a similar temperature-sensitive phenotype. In the presence of rapamycin, G2/M-arrested G1-synchronized wild type cells progress into mitosis at the restrictive temperature, demonstrating that the active conformation of Great1p is required for its function in regulating mitotic entry. In contrast, SIZ1-depleted cells remain arrested in G2/M in the absence of rapamycin, indicating that active SIZ1 is required for the G1-to-S transition. Live cell imaging reveals that the G2/M-arrested SIZ1-depleted cells undergo a mitotic spindle assembly checkpoint-mediated prophase-to-metaphase checkpoint, but do not enter an
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How can I determine which cores will be available?
Most systems have multiple cores, and if I have a dual-core CPU, I should get only half the performance of a system with only one CPU core.
Is there any information that an operating system can gather from a system that can indicate if it will be able to use multiple cores? Ideally, I’d like to measure this myself, but on Windows machines it looks like Device Manager can’t do it, and GKSU won’t report it.
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The only OS you can control is Windows. The other OSs (Mac, UNIX, etc.) have nothing to do with this.
It’s very difficult to enable or disable cores on a machine. They are either enabled by BIOS or they are not. Both Linux and Windows 8/7 enable/disable them by assigning them to a processor group, meaning the OS has a mechanism to switch cores when it needs to (such as running an intensive calculation in one core and a less intensive one in another core when the first core begins to bog down). However, the OS has no way of knowing
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